There are some subtle differences between extractables and leachables. The knowledge of these differences helps select the right sample storage tubes. Poor manufacturing techniques can result in inferior quality products. The extractables are generated over time when the product content comes in contact with the packaging. It usually happens during extreme conditions. For example, the product content may have strong solvent or the temperature may increase.

Leachable compounds can mix up with the drug in a closed container system. The interior lining made of plastic component can cause this problem. Leaching can occur under normal conditions. These compounds are subsets of extractables and can affect the quality of the product in several ways. It is important to maintain the integrity of the sample. It should not come in contact with the plastic tube’s resin. Understanding the properties of such contents help avoid problems caused by the product content coming in contact with the extractables or leachables.